Fastin is a pharmaceutical-grade dietary supplement indicated for weight loss in extremely overweight individuals.
Fastin has booth immediate and delayed release profiles for appetite suppression,
energy, and weight loss. Fastin's pharmaceutical-grade fat loss catalysts
achieve extraordinary results, and is now available without a prescription!
Fastin is a thermogenic intensifier for resounding energy and fat loss. Fastin contains a proprietary blend of Hi-Tech’s most powerful herbal stimulant compounds. At the heart of this herbal marvel is Phenylethylamine HCL and its molecular derivatives, including methylphenylethylamine and methylsynephrine.
Fastin is a true “feel good” product, whose stimulant effects are rapid, yet
exceptionally smooth and clean. So lose fat while you ride a good mood, high-energy
wave throughout the entire day with Fastin!
Although the feeling and effect of Hi-Tech’s Fastin is at least as good as the
original, the formula has changed in significant ways. The old Fastin formula was
formulated around Phentermine HCL, while the new Fastin is formulated around
phenylethylamine HCL and derivatives of this molecule. Phenylethylamine is an
amazing compound that is naturally present in human fluids and tissue. This
compound is probably the cleanest stimulant ever researched, which has the
remarkable ability to stimulate the central nervous system, without causing
nervousness or the jittery feeling. Phenylethylamine is found in chocolate and is
responsible for its effects on mood, appetite, and sense of well-being.
Incenerate Fat – Say Goodbye to your Lovehandles!
Fat mobilization is a new breakthrough in the field of weight loss. As a bariatric
physician (weight-loss physician), I try to stay at the forefront of the diet industry.
The newest thermogenic breakthrough introduced into the market is called Lipid
Mobilization, which helps you burn body fat without exercise. In vitro research
shows that lipid mobilization is one of the processes that releases fat into the
bloodstream to be burned as energy. On the fat cell’s surface are receptors that
signal the cell to hold stored fat. Natural Alpha-2 antagonists have been shown to
switch off these receptors. Freed fatty acids can then move out of the cell and into
the bloodstream. These released fats are shuttled away from fat and prevented from
simply being re-deposited. This is especially effective in the stubborn abdominal and
hip areas of both men and women. Best of all, when taken before exercise, fat
mobilizers are shown to boost lipolysis (the process of mobilizing fats from cells) and
increase blood serum free fatty acid levels both during and after exercise.
The extent of which exercise burns body fat is totally dependent upon the rate of
lipolysis. Lipolysis is the rate at which fat is mobilized from fat cells and enters the
bloodstream as free fatty acids (FFAs). Exercise triggers lipolysis, and highly
trained individuals possess a greater lipolytic rate, an ability to “burn” more fat
during exercise, than untrained people. If you want the greatest possible fat-burning
effect from exercise, then increasing your rate of lipolysis is the way to do it. A high
rate of lipolysis ensures greater fat mobilization by the liver and mitochondria in
muscle cells during exercise. In turn, this process ensures that a greater
concentration of body fat is burnt during exercise. The impact of fat mobilizers on
post-exercise fat metabolism is particularly evident 30 minutes after cardio exercise.
Many physiological factors stimulate and inhibit the breakdown of adipose tissue
into free fatty acids and glycerol and their mobilization into the bloodstream to be
used as fuel by other cells and tissues. Fasting, feeding, exercise, and stress have
pronounced and rapid effects on lipolysis via hormones and other endogenous
substances. As well, clinical conditions such as diabetes and obesity are associated
with alterations in lipolysis. Age and gender are also of importance.
Insulin and catecholamines are the main regulatory hormones of lipid mobilization.
Insulin is the major antilipolytic hormone because of its effects on enzymes within
the adipocyte. Insulin also enables the entry of glucose into the cells by inducing
glucose transporter activity. Glucose serves as the backbone for the glycerol
molecule to which fatty acids attach and form triacylglycerols. The catecholamines
serve a dual function. You must first become acquainted with fat cell biology to
comprehend the regulation of fat loss. Lipogenesis and lipolysis can be considered
the Yin and Yang of adipose tissue metabolism. Lipogenesis is the process of fat
accumulation and lipolysis is that of fat breakdown and release into the
bloodstream.
Fat Mobilizers and Their Unique Fat Burning Abilities:
There are physiological differences in fat cells, depending upon where they
are located in the body. Fat cells located in the gut (visceral adipocytes) differ from
fat cells located in the lower regions of the body (hips, thighs, lovehandles). Fat cells
within the stomach contain a lot of beta-receptors. These cells respond to release fat
when stimulated by the classic “fat-burners,” such as caffeine, ephedrine, and
synephrine. These compounds stimulate lipolysis specifically by increasing
norepinephrine delivery to the visceral fat cells and catecholamine secretion that
activates the beta-receptors and increases CAMP within cells. However, fat cells
located around the hips, and lovehandles characteristically contain very few betareceptors
and respond poorly to catecholamine release that is induced by exercise
and beta-stimulants. However, these lower body fat cells contain a lot of alpha
adrenoreceptors. Alpha-receptors are tricky and obstinate if you want them to
release their fat stores. When stimulated, these receptors activate other proteins that
inhibit adenylcyclase, thus antagonizing the ability of beta-adrenoreceptors to boost
CAMP generation, and therefore, shut down the usual fat mobilization process.
Basically, when taking caffeine, ephedrine, and synephrine supplements in an effort
to stimulate fat loss, the alpha-receptors on lower-body fat cells say “No! No fat
mobilization for you!” Fat cells within the lower half of the body contain a higher
concentration of alpha-receptors and lower concentration of beta-receptors.
Therefore, they are quite resistant to lipolysis. Women characteristically carry more
fat on their hips and thighs than men do, and this difference in fat cell structure is
one reason why most women have a tougher battle with fat loss…Until Now!
Apoptosis – A Novel Approach to Weight Loss
Hi-Tech has recognized for years that the active components in Hi-Tech’s fat loss
products exerted their influence on fat loss through mechanisms of action
attributable to increased lipolysis, decreased Lipogenesis, and more metabolically
desirable fat mobilization. However, over the past five years of Research and
Development, Hi-Tech began testing a theory that some of the beneficial effects of
Lipodrene and Stimerex-ES were also actually due to their effect on elimination
of entire fat cells, or apoptosis. Apoptosis is a form of cell suicide that plays a vital
role in the maintenance of cellular homeostasis, but for weigh loss it causes cell
death (specifically, fat cell death). It was once believed that the total number of
adipocytes (fat cells) remained fairly constant over one’s lifetime; however studies
over the last ten years have shown that adipocytes can be both lost and gained, and
it is becoming increasingly recognized that fat cells have a finite life cycle and can be
eliminated by apoptosis.
Apoptosis is a novel approach to help people lose fat. Since research began several
years ago on this activity of the compounds in Lipodrene, Hi-Tech has been
investigating many plant extracts and other natural substances for their ability to
reduce adipose tissue mass by reducing the number of adipocytes through the
mechanism of apoptosis. We have identified a number of agents that may induce
apoptosis of adipose tissue, and found that some catecholamines and betaadrenergic
receptor agonists are prone to induce adipose tissue apoptosis when
administered orally. These compounds include: clenbuterol, ractopamine,
phenylethylamine, and alkaloids from acacia rigidula extract, including bphenylethylamine, N-Methyl-b-phenylethylamine, and R-betamethylphenylethylamine.
These compounds appear to have the ability to increase the rate of apoptosis in adipose tissue cells, specifically white adipose tissue cells. It is suggested that Fastin’s active components demonstrate a wide array of action on adipocytes, including increased lipolysis, decreased Lipogenesis, decreased cell proliferation, and increased adipogenesis (blocking immature fat cells from maturing and storing lipids). In addition, Fastin assists in more effective lipid mobilization.
Fastin brings forth a trifecta of advancements in the fat loss arena: 1) a
sophisticated manufacturing process that utilizes a dual delivery system technology
for specific control of rapid and sustained release of its active compounds, 2) a
proprietary active compound formulation that trumps the existing field of fat loss
compounds and puts even ephedra in the back seat, 3) a novel approach to fat loss
through triggering fat cell death (apoptosis).
Fastin is a pharmaceutical-grade dietary supplement indicated for weight loss in extremely overweight individuals. Fastin has both immediate and delayed release profiles for appetite suppression, energy, and weight loss. Fastin is comprised of nine pharmaceutical-grade fat loss catalysts at precise ratios in order to achieve its extraordinary results. Fastin’s proprietary formula includes the following:
• R-Beta-methylphenylethylamine HCL – this amazing compound is the active
isomer of MPEA much like 1R, 25 Norephedrine was of PPA years ago. This
compound stimulates norepinephrine unlike any other and leads to appetite
suppression, energy, and ultimate fat loss.
• Methylphenylethylamine tartrate – this is the racemic version of MPEA
bound to tartaric acid, which keeps the molecule stable. This compound is
found in Hi-Tech’s line and is a rising star of the fat loss industry.
• N-methyl-phenylethylamine – is another isolated amine from acacia rigidula
that is both for stimulating fat burning and energizing effects. This is the Nmethyl
derivative of the compound B-Phenylethylamine. This is a very potent
compound for all who lack a chemistry degree.
• Methylsynephrine – is phenolic B-Phenylethylamine found in Acacia
Rigidula and some cacti, which produces considerable nervous system
stimulation (CNS). With Hi-Tech’s research over the past five years on
Acacia Rigidula (as Thermo-Rx®), we have identified and isolated several
key phenylethylamine alkaloids. The newest of which is methylsynephrine.
The alkaloids from the acacia rigidula are biologically and physiologically
similar to those found in ephedra, and possess properties that are shared
with ephedra alkaloids. Scientifically, this is in part due to the similarities in
pharmacokinetics and pharmacodynamics. The most obvious similarity is
that acacia alkaloids, like the ephedra alkaloids, readily pass into the brain.
The main factor governing the transfer of small molecules into the central
nervous system is lipophilicity.
The distribution of drugs and/or compoundsinto the CNS from the blood is unique, because functional barriers arepresent that restrict entry of drugs into this critical site. One reason for thisis that the brain capillary endothelial cells have continuous tight junctions; therefore, drug penetration into the brain depends on transcellular rather than paracellular transport between cells. The unique characteristics of percipaillary gilial cells also contribute to the blood-brain barrier. At the choroids plexus, a similar blood-cerebrospinal fluid (CSF) barrier is present, except that it is epithelila cells that are joined by tight junctions rather than endothelial cells. As a result, the lipid solubility of the nonionized and unbound species of the drug is an important determinant of its uptake by the
brain; the more lipophilic it is, the more likely it is to cross the blood-brain
barrier. This situation is used in drugs design to alter the brain distribution,
which is the case with drugs like amphetamine, phentermine, and
benzphetamine. As you can see from the comparison of the structures of
ephedrine, norephedrine, and methylsynephrine they all possess the b-methyl
substituent of the aliphatic sidechain, which is characteristic of ephedrine
and its congeners, as well as methylsynephrine, thus further increasing
lipophilicity.
What is a suitable substitute for ephedra? How about another beta-agonist?
Methylsynephrine is just the answer that the industry has been waiting on for
years! The sympathetic nervous system is involved in the regulation of
energy. Therefore, pharmacological manipulation of the system offers a
mechanism of targeting a reduction in excess body fat stores. Many betaadrenergic
agonists are known to increase muscle mass while concurrently
decreasing fat mass. Prolonged treatment with sympathomimetic compounds
reduces energy intake and increases energy expenditure. The beta 2&3
receptors appear to be responsible for the lipolytic and thermogenic effects of
adrenergic agents, while interaction with beta-1 and to a much lesser extent,
beta-2 control cardiac effects. Accordingly, the ideal fat loss compound would
be one identical to acacia rigidula and especially methylsynephrine. Until
now, there has never been a beta-adrenergic compound like
methylsynephrine that can stimulate lipolysis and increase resting metabolic
rate like ephedra.
• Theobromine – is the primary methylxanthine found in products of the cocoa
tree, Theobroma cocao. As a member of the methylxanthine family, it is
thought to elevate levels of serotonin, the same action as the popular antidepressants.
Theobromine has a lot of research that shows its extraordinary
effects on fat loss, appetite suppression, and mobilization of fatty deposits.
Theobromine acts as a mild diuretic and stimulant, which creates a
synergistic effect with caffeine.
• Phenylethylamine HCL – this amazing compound is probably the cleanest
stimulant ever researched, and it is naturally present in human fluids and
tissues. Although categorized as a stimulant, it has the remarkable ability to
simulate the central nervous system without causing nervousness or the
jittery feeling. Phenylethylamine is found in chocolate and is responsible for
its effects on mood, appetite, and sense of well-being. Until recent discoveries,
PEA, or phenylethylamine, was rapidly destroyed within the body. If
included with novel delivery systems, phenylethylamine HCL is provided
“safe transport” and this metabolic fate is avoided and pharmacological
activity becomes extremely apparent. This catecholamine precursor is
responsible for elevating the metabolic rate and promoting a sense of satiety.
Phenylethylamine acts on alpha-receptors in the brain, as do norepinephrine
and certain prescription anti-obesity drugs. It is also believed to cause the
release of dopamine in the pleasure sensing areas of the brain.
Phenylethylamine HCL has a close chemical relationship to pharmaceutical
stimulants, because it is the “backbone” of many pharmaceutical
compounds.
• Yohimbine HCL – has been shown in many clinical trials to effectively block
alpha 2 adrenoreceptors. These studies have found that yohimbine increases
the amount of non-esterfied fatty acids (NEFA’s) a product of lipolysis (the
breakdown of fat), in the blood-stream for both lean and overweight
subjects. There are a number of feedback mechanisms that prevent the
release of norepinephrine (NE), one of the body’s primary lipolytic
hormones. When NE is released, such as when taking methylsynephrine and
acacia rigidula, it stimulates both the alpha and beta adrenoreceptors.
Stimulation of the beta adrenoreceptors has the opposite effect, preventing
the release of NE and lipolysis. Yohimbine prevents this negative feedback
mechanism, and works in a synergistic fashion with the other components to
increase NE and lipolysis. There are a number of reasons why alpha-2
inhibition is specifically useful. First, while the beta-adrenergic system
primarily controls lipolysis during periods of intense activity, during rest,
which makes up most of our day, the alpha-adrenergic system is in control.
Also, “stubborn fat” areas – usually the abdominal area in men and the
glutofemoral area in women – contain a higher ratio of alpha-2 receptors,
making yohimbine particularly effective in these areas (whereas other drugs
that increase NE may be somewhat counterproductive). Finally, alpha-2
blockade increases blood flow in adipose tissue, which prevents fat from
being retained in the area.
• Synephrine HCL – is a drug used primarily in fat loss, although the
effectiveness is minimal in Fastin. It is very popular and has been used as an
alternative to ephedrine (a substance with a history of controversy).
Synephrine is derived primarily form the fruit of a small citrus tree.
• Caffeine Anhydrous USP – acts as a stimulant and thermogenic in humans,
and is commonly taken to boost energy or mental concentration. It will
stimulate the central nervous system and the metabolism. Once metabolized,
caffeine can increase lipolysis in the body. Caffeine may also increase the
effectiveness of other substances such as ephedrine or yohimbe, and was
incredibly popular in the commonly used ECA stack (ephedrine, caffeine,
and aspirin).
Fastin by Hi-Tech Pharmaceuticals not only welcomes the challenge of living up to a legend, but chose the name in order to have a tell set of shoes to fill. Fastin is a world class fat burner that will help anyone needing to lose weight. Whether you need to lose a little or a lot of weight – Fastin is just what you need!
